Treatment of subcutaneous and intracranial brain tumor xenografts withO6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea
β Scribed by G. Michael Felker; Henry S. Friedman; M. Eileen Dolan; Robert C. Moschel; Clifford Schold
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 737 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0344-5704
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## Abstract During chemotherapy and regrowth of brain tumors, tumorβcell heterogeneity, and possibly tumor progression, may change as a result of both the selective forces and mutagenic effects of treatment. We have isolated and characterized drugβresponse variants of multicellular rat 9L brainβtum
Pretreatment of 9L cells with either a-difluoromethylornithine (DFMO), which depletes intracellular levels of polyamines, or 6-thioguanine (6TG). which substitutes for guanine in DNA, potentiates the cytotoxic effects of 1,3-bis (2-chloroethy1)-I -nitrosourea (BCNU). We examined the effects of these