✦ LIBER ✦

Treatment of refractory large granular lymphocytic leukemia with 2-chlorodeoxyadenosine

✍ Scribed by Edelman, Martin J.; O'Donnell, Robert T.; Meadows, Ivan

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 125 KB
Volume: 54
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199704)54:4<329::aid-ajh13>3.0.co;2-6

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✦ Synopsis

A 50-year-old man with large granular lymphocytic leukemia (CD3+, CD8+) complicated by severe pancytopenia and life-threatening infections refractory to therapy with prednisone, methotrexate, cyclosporine, and G-CSF is described. Treatment with two cycles of 2-chlorodeoxyadenosine (2-CDA) at 0.1 mg/kg by continuous intravenous infusion for 7 days each cycle resulted in resolution of cytopenias and clearance of leukemic cells. T-cell receptor gene rearrangement, initially present, was not detectable after therapy with 2-CDA. The rapid and complete response to 2-CDA after unsuccessful attempts with prior therapy suggests that 2-CDA should be considered for initial treatment of this disorder.

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