Thirty-eight patients with metastatic colorecal carcinoma were treated with 5-fluorouracil (5-FU), and 38 patients were treated with the combination of 5-FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the
Treatment of metastatic colorectal carcinoma with 5-fluorouracil by mouth
โ Scribed by S. R. Lahiri; G. Boileau; T. C. Hall
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 993 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0008-543X
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## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity
In order to redefine the effectiveness of 5-fluorouracil (5-FU) as palliative therapy in patients with metastatic colorectal carcinoma, and to compare the effectiveness of 6-thioguanine (6-TG) with that of 5-FU, we studied 176 patients with metastatic colorectal carcinoma in a randomized prospective
## BACKGROUND. The combination of 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (l-OHP) was shown to be both more active against metastatic colorectal carcinoma and better tolerated if the drug delivery rate was chronomodulated according to circadian rhythms rather than constant. This all