𝔖 Bobbio Scriptorium
✦   LIBER   ✦

TREATMENT OF CHILDREN WITH HISTIOCYTOSIS

✍ Scribed by M. M. Reid; G. R. Burgio; M. Aricog; M. Marconi; A. Lanfranchi; D. Caselli; A. G. Ugazio

Book ID
114712084
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
171 KB
Volume
75
Category
Article
ISSN
0007-1048

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Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.

β€œEtoposide in the treatment of six child
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Viana et al. [I] described their experience with etoposide (VP-16) as initial therapy in the management of patients with Langerhans cell histiocytosis (LCH). However, caution should be used in advocating the use of an epipodophyllotoxin as the "drug of choice" for the treatment of this disorder. Alt

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## Abstract Fifty‐two pediatric patients with Langerhans cell histiocytosis (LCH) were diagnosed at the Emma Kinderziekenhuis (EKZ) in Amsterdam over a 20‐year period. Eight patients with multiorgan involvement with organ dysfunction and ten patients with multiorgan involvement without organ dysfun