Treatment of chemotherapy-resistant advanced ovarian cancer with a combination of cyclophosphamide, hexamethylmelamine, adriamycin, and cis-diamminedichloroplatinum (CHAP)
β Scribed by H.W. Bruckner; C.J. Cohen; G. Deppe; B. Kabakow; R. Wallach; L. Ratner; James F. Holland
- Book ID
- 119052072
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 258 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0090-8258
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Fifty-one patients with ovarian cancer were tients with < 2 cm residual disease had sigentered in a randomised trial comparing treat-nificantly higher rate of complete remission rnent with cisplatin + adriamycin + cyclo-than those with > 2 crn residual disease. Carphosphamide (PAC) to cisplatin + 4'
Fourteen patients with advanced head and neck carcinomas received a monthly intravenous regimen of Adriamycin, 40 mg/m2, day 1; cyclophosphamide, 400 mg/m2, day 3; and cis-diamminedichloroplatinum, 20 mg/m2/1 hour, days 1-3 (CAP-3). A regression rate of only 7% (0112 squamous cell carcinomas; 112 ad