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Treatment of advanced malignant melanoma with high dose methotrexate and folinic acid rescue

✍ Scribed by Leahy, Michael F. ;Silver, Hulbert K. B. ;Klimo, Paul ;Hall, Thomas C.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
366 KB
Volume
10
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Twenty‐eight patients with advanced malignant melanoma were treated with high dose methotrexate (HDMTX) and folinic acid (FA) rescue. Nineteen patients were treated with 6‐hour infusions and 10 patients with 24‐hour infusions. One patient in the 6‐hour infusion group showed a partial response. In the 24‐hour infusion group there were no responses but there was a significant increase in renal toxicity. It is concluded that HDMTX and FA rescue are not useful agents in the treatment of advanced malignant melanoma.

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