Treatment of advanced head and neck cancer by means of radiation therapy plus chemotherapy — a randomised trial

✍ Scribed by Bezwoda, Werner R. ;de Moor, Norah G. ;Derman, Denis P.

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 350 KB
• Volume: 6
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950060412

✦ Synopsis

Fifty-eight patients with advanced head and neck cancer were entered into a randomised trial comparing radical radiation therapy to the primary tumour and associated lymph node areas with a combination of radiation therapy plus chemotherapy. The distribution of tumour types and stages was similar in the two treatment groups. The response rates to radiation therapy alone (50% complete plus parital response) and to radiation therapy plus chemotherapy (60% complete plus partial response) were not significantly different. However, a significant difference in survival was found between the two groups. The median duration of survival for the patients treated by means of radiation therapy alone was 18 weeks; that for the combined therapy was 36 weeks. The combination of radical radiation therapy plus intermittent high-dose chemotherapy was well tolerated and appears to be an approach that warrants further trial.