𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Treatment of adult acute lymphoblastic leukaemia using an intensive chemotherapy protocol

✍ Scribed by R. Liang; T. K. Chan; G. T. C. Chan; D. Todd

Publisher
Springer
Year
1989
Tongue
English
Weight
476 KB
Volume
23
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.

✦ Synopsis

A total of 25 evaluable adult patients with acute lymphoblastic leukaemia (ALL) were treated with an intensive chemotherapy regime modified from the L17/L17M protocol of the Sloan-Kettering Hospital. There were 18 men and 7 women; their median age was 36 years (range, 13-78). Seven cases had L1 morphology and 18, L2. The immunophenotype was common-ALL in 10, null-ALL in 9, T-ALL in 4 and B-ALL in 1. Of the 25 patients, 14 (56%) achieved a complete remission (CR). The causes of induction failure were partial remission (PR) only in 7 (28%) and hypoplastic death in 4 (16%). Of the 14 CR patients, 11 (78.6%) relapsed. Five patients developed CNS disease. The median disease-free survival and overall survival were only 9 and 13 months, respectively. As the follow-up periods of the surviving patients were short, late relapses may still occur and the overall treatment result is likely to be worse on longer follow-up. The possible causes of this disappointing result are discussed.

πŸ“œ SIMILAR VOLUMES

Improved treatment outcome in adult acut
Improved treatment outcome in adult acute lymphoblastic leukemia using the intensive German protocol, a preliminary report
✍ C. S. Chim; Y. L. Kwong; Y. C. Chu; C. H. Chan; Y. T. Chan; Raymond Liang πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 54 KB πŸ‘ 2 views

Thirty-nine consecutive patients with acute lymphoblastic leukemia were treated with an intensive chemotherapy protocol. There were 23 males and 16 females with a median age of 37 years (range: 15-65). Eighteen patients had common ALL, seven had pre-B ALL, three early-precursor B ALL, seven T-ALL an

Successful treatment of relapsed infant
Successful treatment of relapsed infant acute lymphoblastic leukemia with intensive antimetabolite-based chemotherapy
✍ Barredo, Julio C.; Yusuf, Usman; Abboud, Miguel; Laver, Joseph πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 47 KB πŸ‘ 2 views

The treatment of infant acute lymphoblastic leukemia (ALL) continues to be a significant challenge for pediatric oncologists due to the high incidence of early relapses. Salvage regimens used to date have met limited success. We describe two cases of relapsed infant ALL who have achieved long-term s

Treatment of childhood acute myeloid leu
Treatment of childhood acute myeloid leukaemia using the BFM-83 protocol
✍ Sartori, Patricia C. E. ;Taylor, Mary H. ;Stevens, Michael C. G. ;Darbyshire, Ph πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 587 KB

## Abstract Thirty children presenting with acute nonlymphoblastic leukaemia from June 1984 to December 1989 were treated at one UK centre using a West German protocol, AML‐BFM‐83. This consisted of induction, an intensive outpatient‐based Consolidation regimen with seven different drugs and crania