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Reduced elimination of Methotrexate in an adult with trisomy 21 and acute lymphoblastic leukaemia

✍ Scribed by Jecko Thachil


Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
58 KB
Volume
31
Category
Article
ISSN
0145-2126

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The t(1;19)(q23;p13), detected cytogenetically in 5-6% of cases, is one of the most common translocations in childhood acute lymphoblastic leukemia (ALL). Most t(1;19)Ο© ALLs are pseudodiploid or contain fewer than 50 chromosomes, are classified as pre-B based on expression of cytoplasmic, but not su