The effects of N4-behenoyl-l-~-~-arabinofuranosylcytosine (BH-AC) on the cell cycle of murine leukemic cells (L 1210 cells) were compared with those of 1-8-D-arabinofuranosylcytosine (ara-C), known to be effective for acute leukemia. In a cytokinetic study, a combination of Feulgen microcytofluorome
Treatment of acute myelogenous leukemia in adults with N4-behenoyl-1-β-D-arabinofuranosylcytosine
✍ Scribed by Kiyoji Kimura; Ryuzo Ohno; Ichita Amaki; Kenichi Hattori; Yutaka Hirota; Akira Hoshino; Michito Ichimaru; Munemoto Ito; Ikuo Kimura; Tadashi Maekawa; Toru Masaoka; Toru Nakamura; Makoto Ogawa; Masao Oguro; Kazuo Ohta; Shigeyuki Osamura; Masanori Shimoyama; Fumimaro Takaku; Yoshiro Uzuka; Kazumasa Yamada
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 438 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0008-543X
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N4-alkyl-I -P-D-arabinofuranosyl cytosines as lipophilic derivatives of the widely used anti-tumor drug I -P-D-arabinofuranosylcytosine (ara-C) were synthesized and incorporated into unilamellar liposomes. The resulting preparations yielded stable unilamellar liposomes with diameters ranging between