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Treating hypercholesterolaemia with HMG CoA reductase inhibitors: a direct comparison of simvastatin and pravastatin

✍ Scribed by Lintott, C. J. ;Sutherland, W. H. F. ;Scott, R. S. ;Bremer, J.


Book ID
119844078
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
469 KB
Volume
23
Category
Article
ISSN
0004-8291

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Relative lipophilicities, solubilities,
✍ Abu T. M. Serajuddin; Sunanda A. Ranadive; Eileen M. Mahoney πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

The apparent octanol-water partition coefficients (Po/w) and aqueous solubilities for four 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors [pravastatin, lovastatin (mevinolin), mevastatin (compactin), and simvastatin (synvinolin)] were compared. Pravastatin is highly hydrophilic