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Trastuzumab induces antibody-dependent cell-mediated cytotoxicity (ADCC) in HER-2-non-amplified breast cancer cell lines

✍ Scribed by Collins, D. M.; O'Donovan, N.; McGowan, P. M.; O'Sullivan, F.; Duffy, M. J.; Crown, J.

Book ID
111899718
Publisher
Oxford University Press
Year
2012
Tongue
English
Weight
431 KB
Volume
23
Category
Article
ISSN
0923-7534

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## Abstract Two members of the EGF receptor family, HER2 and HER3, act as key oncogenes in breast cancer cells. A MAb against HER2, trastuzumab, interferes with HER2 signaling and istherapeutically effective in humans. Here, we explored the biologic effects of an antibody against HER3 (α‐HER3^ECD^)