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EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance

✍ Scribed by Rajiv Dua; Jianhuan Zhang; Phets Nhonthachit; Elicia Penuel; Chris Petropoulos; Gordon Parry


Publisher
Springer US
Year
2009
Tongue
English
Weight
627 KB
Volume
122
Category
Article
ISSN
0167-6806

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bcl-2 expression is often associated with poor prognosis in several types of tumors; however, the role of this molecule in breast cancer is still controversial. We found earlier that over-expression of bcl-2 in a human breast-cancer cell line (MCF7 ADR ) enhances its tumorigenicity and metastatic po