Trastuzumab-based neoadjuvant therapy in patients with HER2-positive breast cancer
โ Scribed by Helena R. Chang
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 348 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND: Several large, randomized trials established the benefits of adjuvant trastuzumab with chemotherapy. However, the benefit for women with small, nodeโnegative HER2โpositive (HER2+) disease is unknown, as these patients were largely excluded from these trials. Therefore, a
## Abstract ## BACKGROUND: Only a portion of breast cancer patients currently selected for trastuzumab therapy respond. ## METHODS: Using a novel assay (HERmark) to quantify total human epidermal growth factor receptor 2 (HER2) expression, the authors examined outcomes in 102 trastuzumabโtreated
## Abstract Herโ2/__neu__ overexpression in human breast cancer leads to an aggressive biological behavior and poor prognosis. Although the antiโHerโ2/__neu__ antibody trastuzumab (Herceptinยฎ) has become a valuable therapeutic option for patients with Herโ2/__neu__โoverexpressing breast cancer, man