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Transthyretin Induced Amyloidosis Interactions, Mechanisms and Potent Drugs Design

✍ Scribed by Jakubowski, Rafal; Skrzyniarz, Piotr; Peplowski, Lukasz; Nowak, Wieslaw


Book ID
123346361
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
41 KB
Volume
106
Category
Article
ISSN
0006-3495

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The polymorphic and/or pseudo-polymorphic phase transformation of Drug Z API, from Form I to Form II, occurs during the wet granulation step. It was observed that dissolution of the tablets slowed down under certain manufacturing conditions. Factors responsible for the slowdown in tablet dissolution