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Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: a thermal–mechanical facilitated process-induced transformation or PIT

✍ Scribed by Wang, Jennifer (author);Davidovich, Martha (author);Desai, Divyakant (author);Bu, Dongsheng (author);Hussain, Munir (author);Morris, Kenneth (author)

Publisher
John Wiley and Sons Inc.
Year
2010
Tongue
English
Weight
799 KB
Volume
99
Category
Article
ISSN
0022-3549

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Solid-state interactions of a drug subst
Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: a thermal–mechanical facilitated process-induced transformation or PIT
✍ Wang, Jennifer (author);Davidovich, Martha (author);Desai, Divyakant (author);Bu 📂 Article 📅 2010 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 799 KB

The polymorphic and/or pseudo-polymorphic phase transformation of Drug Z API, from Form I to Form II, occurs during the wet granulation step. It was observed that dissolution of the tablets slowed down under certain manufacturing conditions. Factors responsible for the slowdown in tablet dissolution