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Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma

✍ Scribed by Jeng-Long Hsieh; Che-Hsin Lee; Min-Li Teo; Yih-Jyh Lin; Yen-Sung Huang; Chao-Liang Wu; Ai-Li Shiau


Book ID
108586403
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
328 KB
Volume
100
Category
Article
ISSN
1347-9032

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## Abstract ## Background Although cancer therapy using replication‐selective oncolytic adenoviruses has been available for many years, its anti‐tumor efficacy is suboptimal as a result of low and nonspecific infectivity that depends on coxsackie adenovirus receptor expression of the target cancer