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Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model

✍ Scribed by Timme, T L; Nasu, Y; Bangma, C H; Hull, G W; Lee, H-M; Hu, J; Wang, J; McCurdy, M A; Shimura, S; Yang, G

Book ID: 110038361
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 980 KB
Volume: 6
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3300834

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It is critical to develop new therapies, such as gene therapy, which can impact on both local and metastatic prostate cancer progression. We have developed an orthotopic mouse model of metastatic prostate cancer using a cell line (RM-1) derived from the mouse prostate reconstitution (MPR) model syst