✍ Scribed by G.R.A. Hunt
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Several #-diketones (R.CO.CH2.CO.R.) with R groups similar to those used in NMR shift reagents have been investigated as carriers for the transport of Pr 3* ions across phospholipid vesicular membranes. Only the flourinated diketone fod (l,l,l,2,2,3,3-heptafluoro-7.7dimethyloctane-4,6 dione) gave a transport rate which approached that obtained using the calcium ionophore A23187. It was established that the NMR method used to follow the kinetics gave an experimental stoichiometry of Pr(fod)2. s for an expected transported complex Pr(fod)3. The advantages of using an NMR method for studying facilitated transport in vesicular membrane systems are discussed, in particular their use in determining stoichiometries of transported species.
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## Abstract 1,2,3,4,6‐Penta‐__O__‐galloyl‐β‐D‐glucopyranose (PGG) is a polyphenolic compound found in substantial amounts in a number of medicinal herbs. We report (i) its conformational analysis by solution NMR and molecular dynamics calculation and (ii) theoretical study of its interaction with a