✦ LIBER ✦
Conformation of the tridimensional structure of 1,2,3,4,6-pentagalloyl-β-D-glucopyranose (PGG) by 1H NMR, NOESY and theoretical study and membrane interaction in a simulated phospholipid bilayer: a first insight
✍ Scribed by Giangiacomo Beretta; Roberto Artali; Enrico Caneva; Roberto Maffei Facino
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 245 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0749-1581
- DOI
- 10.1002/mrc.2718
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✦ Synopsis
Abstract
1,2,3,4,6‐Penta‐O‐galloyl‐β‐D‐glucopyranose (PGG) is a polyphenolic compound found in substantial amounts in a number of medicinal herbs. We report (i) its conformational analysis by solution NMR and molecular dynamics calculation and (ii) theoretical study of its interaction with a model membrane bilayer. The galloyl groups B and E appear to play important roles in the interaction with the phospholipid bilayer. Copyright © 2011 John Wiley & Sons, Ltd.