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Transport of a 1D viscoelastic actin–myosin strip of gel as a model of a crawling cell

✍ Scribed by Kamila Larripa; Alex Mogilner

Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
234 KB
Volume
372
Category
Article
ISSN
0378-4371

No coin nor oath required. For personal study only.

✦ Synopsis

Cell crawling is an important biological phenomenon because it underlies coordinated cell movement in morphogenesis, cancer and wound healing. This phenomenon is based on protrusion at the cell's leading edge, retraction at the rear, contraction and graded adhesion powered by the dynamics of actin and myosin protein networks. A few one-dimensional models successfully explain an anteroposterior organization of the motile cell, but don't sufficiently explore the viscoelastic nature of the actin-myosin gel. We develop and numerically solve a model of a treadmilling strip of viscoelastic actin-myosin gel. The results show that the strip translocates steadily as a traveling pulse, without changing length, and that protein densities, velocities and stresses become stationary. The simulations closely match the observed forces, movements and protein distributions in the living cell.

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