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Transport across the blood-brain barrier: stereoselectivity and PET-tracers

✍ Scribed by Gert Luurtsema; Elizabeth C.M. de Lange; Adriaan A. Lammertsma; Eric J.F. Franssen


Book ID
116748078
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
414 KB
Volume
6
Category
Article
ISSN
1536-1632

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## Abstract In adult rats, using the single‐pass brain uptake technique with a tritiated water standard, L‐phenylalanine was shown to enter brain across the blood‐brain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0