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Drug transport across the blood-brain barrier

✍ Scribed by Bree, J. B. M. M. ;Boer, A. G. ;Danhof, M. ;Breimer, D. D.


Publisher
Springer
Year
1993
Tongue
Dutch
Weight
986 KB
Volume
15
Category
Article
ISSN
1573-739X

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## Abstract In adult rats, using the single‐pass brain uptake technique with a tritiated water standard, L‐phenylalanine was shown to enter brain across the blood‐brain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0