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Transplantation immunity in the axolotl (Ambystoma mexicanum) studied by blastemal grafts

✍ Scribed by de Both, N. J.

Publisher: John Wiley and Sons
Year: 1970
Tongue: English
Weight: 844 KB
Volume: 173
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1401730204

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✦ Synopsis

Abstract

To verify data in the older literature concerning the survival of allografts in the axolotl, a transplantation‐immunological study was carried out in this species. Animals were used from four randomly bred laboratory populations, partly related and partly unrelated. Tolerance for blastemal allografts was shown at 20°C within two of the populations. In one of these the animals were provided with second and third set grafts, which were also tolerated. Allografts exchanged between larvae of related populations always showed prolonged survival. In contrast, grafts exchanged between non‐related populations were frequently rejected. In some cases this rejection was incomplete and was followed by regeneration. Axolotls which tolerated allografts nevertheless rejected blastemal xenografts from other urodelean species. It is concluded that neither immunological unresponsiveness of the host larvae, nor lack of antigenicity of the blastemal grafts is responsible for the prolonged survival of allografts, but that genetic relatedness is the main factor involved.

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