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Transparent micro- and nanopatterned poly(lactic acid) for biomedical applications

✍ Scribed by Christopher A. Mills; Melba Navarro; Elisabeth Engel; Elena Martinez; Maria Pau Ginebra; Josep Planell; Abdelhamid Errachid; Josep Samitier

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
348 KB
Volume
76A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

The formation of structures in poly(lactic acid) has been investigated with respect to producing areas of regular, superficial features with dimensions comparable to those of cells or biological macromolecules. Nanoembossing, a novel method of pattern replication in polymers, has been used for the production of features ranging from tens of micrometers, covering areas up to 1 cm^2^, down to hundreds of nanometers. Both micro‐ and nanostructures are faithfully replicated. Contact‐angle measurements suggest that positive microstructuring of the polymer (where features protrude from the polymer surface) produces a more hydrophilic surface than negative microstructuring. The ability to structure the surface of the poly(lactic acid), allied to the polymer's postprocessing transparency and proven biocompatibility, means that thin films produced in this way will be useful for bioengineers studying the interaction of micro‐ and nanodimensioned features with biological specimen, with regard to tissue engineering, for example. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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