Transmission of the conformational information in the antisense/RNA hybrid duplex influences the pattern of the RNase H cleavage reaction

The recognition and cleavage of RNA in t

The recognition and cleavage of RNA in the antisense oligo–RNA hybrid duplexes by RNase H

✍ N.V Amirkhanov; E Zamaratski; J Chattopadhyaya 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 160 KB

The different extent of the target RNA cleavage at t 99.9% by RNase H in the AON-RNA duplexes, at the RNA saturation condition by antisense oligo, is due to different recognition and catalytic properties of RNase H toward the hybrids owing to different substituents at the 3%-end of the AONs, not owi