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The recognition and cleavage of RNA in the antisense oligo–RNA hybrid duplexes by RNase H

✍ Scribed by N.V Amirkhanov; E Zamaratski; J Chattopadhyaya

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
160 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The different extent of the target RNA cleavage at t 99.9% by RNase H in the AON-RNA duplexes, at the RNA saturation condition by antisense oligo, is due to different recognition and catalytic properties of RNase H toward the hybrids owing to different substituents at the 3%-end of the AONs, not owing to the different thermodynamic stabilities of the antisense oligonucleotide (AON)-RNA duplexes.

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