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Transmembrane domain of EphA1 receptor forms dimers in membrane-like environment

✍ Scribed by Elena O. Artemenko; Natalya S. Egorova; Alexander S. Arseniev; Alexey V. Feofanov


Book ID
116274671
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
508 KB
Volume
1778
Category
Article
ISSN
0005-2736

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Dimerization models of c-erbB2 transmembrane domains (Leu651-Ile675) are studied by molecular mechanics and molecular dynamics simulations. Both wild and Glu mutated transmembrane helices exhibit the same relative orientation for favorable associations and dimerize preferentially in left-handed coil