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Three dimensional structures and topology of the transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environments

✍ Scribed by Hongyan Li; Fei Li; Qing-Yu He; Zhong-Ming Qian; Hongzhe Sun


Book ID
108403884
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
81 KB
Volume
96
Category
Article
ISSN
0162-0134

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## Abstract DMT1, also known as Nramp2, is an iron transporter, and belongs to the family of Nramp proteins. Disease‐causing mutations both in Nramp1 and Nramp2 occurring at the conserved two adjacent glycine residues located within the fourth transmembrane domain (TM4) suggest that TM4 may serve a