Translocation of long peptides by transporters associated with antigen processing (TAP)
✍ Scribed by Jens-Oliver Koopmann; Markus Post; Jacques J. Neefjes; Günter J. Hämmerling; Frank Momburg
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 963 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
TAP1 and TAP2 molecules are involved in the transport of peptides prior to their association with class I molecules and are mandatory for efficient antigen presentation. To investigate whether loss of expression of TAP1 or TAP2 is a likely mechanism of immune escape in malignant melanoma, TAP1 and T
Stable cell surface presentation of HLA class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which map in the major histocompatibility complex class II region. Alleles of each gene are derived from a combination o