Translocation of compact polymer chains through a nanopore
โ Scribed by Zhiyong Yang; Zhengquan Pan; Linxi Zhang; Haojun Liang
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 695 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0032-3861
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โฆ Synopsis
We perform dynamical Monte Carlo simulation to study the forced translocation of compact polymer chains in three-dimensional lattices. The chains are driven through a nanopore connecting two infinite channels by an external field. The scaling properties of average translocation time s and translocation time distribution (TTD) are studied. The effects of contact energy (3 C ), electric field strength (E), and nanopore width (L) on the scaling exponent (a) of average translocation time s w N a and the TTD are investigated. For the scaling behavior of s w N a , we have found that there is no crossover behavior with weak field strength when the nanopore width is one lattice spacing, which is less than average bond length, while crossover behaviors are observed for larger nanopore widths. The scaling exponent a also depends on contact energy 3 C and electric field strength E. For the TTD, it shifts from the Gaussian to a right-skew distribution with the electric field E increasing for short chains; while for long chains, multipeak distributions are observed. As a primary and simple model, compact polymer chains are extensively used to capture the structure and thermodynamic properties of proteins, therefore we can investigate the protein translocation by simulating compact chain translocation, and this study will be useful for exploring the complex translocation behaviors of proteins.
๐ SIMILAR VOLUMES
The driven translocation dynamics of a polynucleotide chain through a nanopore is studied using off-lattice Monte-Carlo simulations, which plays an important role in the nanopore sequencing of polynucleotides. We report a detailed study on the dependence of translocation dynamics on the chain length