Translocation (2;13) and other chromosome abnormalities in intraosseous schwannoma of the mandible
โ Scribed by Esther Manor; Sarit Tetro; Monica Noyhous; Palina Kachko; Lipa Bodner
- Book ID
- 113513571
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 119 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0165-4608
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The chromosomal translocation t(2;13)(q35;q14) has been reported in alveolar paediatric rhabdomyosarcoma. The rearrangement leads to the juxtaposition of the PAX-3 and FORKHEAD genes and the production of a fusion protein with putative transcriptional regulatory activity. The diagnostic potential of
Rhabdomyosarcoma, a small-. round-cell tumor of skeletal muscle, is the most common soft tissue sarcoma found in children. A specific and unique chromosomal translocation, t(2;13)(q35;q14), has been described cytogenetically in a subset of these tumors and is most often associated with the alveolar