Translocation 1;7 in four cases of myeloid disorders
โ Scribed by David M. Sheppard; Kathleen E. Richkind; Murlin Bull
- Book ID
- 119104175
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 208 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
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## Abstract The 8p11 myeloproliferative syndrome (EMS) is associated with three translocations, t(8;13)(p11;q12), t(8;9)(p11;q33), and t(6;8)(q27;p11), that fuse unrelated genes (__ZNF198, CEP110,__ and __FOP__, respectively) to the entire tyrosine kinase domain of __FGFR1__. In all cases thus far
## Abstract Bone marrow cells of four patients with t(1;7) and myelodysplasia or acute myeloid leukemia were analyzed using nonradioactive in situ hybridisation. As probes, centromeric alphoid DNA sequences of chromosomes 1 and 7, a satellite DNA probe for 1q12, and chromosomespecific libraries of