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Translational control by the poly(A) binding protein: A check for mRNA integrity

✍ Scribed by Yu. V. Svitkin; N. Sonenberg


Book ID
110174365
Publisher
SP MAIK Nauka/Interperiodica
Year
2006
Tongue
English
Weight
163 KB
Volume
40
Category
Article
ISSN
0026-8933

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The poly(A)-binding protein is required
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Depletion of the essential poly(A)-binding protein (PAB) in Saccharomyces cerevisiae by promoter inactivation or by the utilization of a temperature-sensitive mutation (pab1-F364L) results in the inhibition of translation initiation and poly(A) tail shortening1. Reversion analysis of pab1-F364L yiel