## Abstract Kinetic isotope effects (KIEs) have been found to be the most powerful tool available to physical organic chemists for determining the mechanism of reactions and for estimating the structure of their transition states. Various types of KIEs including primaryβleaving groupβ, nucleophileβ
Transition state structures in glycosidase catalysis: kinetic isotope effects and structure-reactivity parameters
β Scribed by A.C. Elliott; B.F. Li; C.A.J. Morton; J.D. Pownall; T. Selwood; M.L. Sinnott; I.J.L. Souchard; A.K. Stuart-Tilley
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 505 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0304-5102
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## Abstract Complexation of dihydrogen to transition metal centers was discovered by Kubas and coworkers in 1984. The notion that the simplest molecule in chemistry can act as a ligand to form relatively stable transition metal complexes has led to a paradigm shift in coordination chemistry. Crucia
l unimolecul-ar hydrogen eliminations from carbocations are currently interpreted in terms of a concerted mechanii in which two C-H bonds are synchronously stretched. Here we show, through MNDO and RR-1 computations, that the available experimental data are compatible with all the reaction mechanism