✦ LIBER ✦

Determining transition state structure using kinetic isotope effects

✍ Scribed by Kenneth C. Westaway

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 358 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1434

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✦ Synopsis

Abstract

Kinetic isotope effects (KIEs) have been found to be the most powerful tool available to physical organic chemists for determining the mechanism of reactions and for estimating the structure of their transition states. Various types of KIEs including primary‐leaving group‐, nucleophile‐, and α‐carbon KIEs and secondary alpha‐ and beta‐deuterium KIEs are introduced. The factors that affect the magnitude of each of these KIEs are covered in some detail. Finally, the use of these KIEs to determine the mechanism of a reaction and to estimate the structure of the transition state for a reaction is discussed. Copyright © 2007 John Wiley & Sons, Ltd.

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