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Transition metal complexes in organic synthesis, part 54. Improved total syntheses of the antibiotic alkaloids carbazomycin A and B

✍ Scribed by Hans-Joachim Knölker; Wolfgang Fröhner

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
228 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Considerably improved total syntheses of the carbazole antibiotics carbazomycin A and B are reported using a convergent iron-mediated one-pot construction of the carbazole framework by oxidative cyclization in the air.

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The first total synthesis of the carbazole quinol alkaloids carbazomycin G and H has been achieved by a highly convergent synthesis using an iron-mediated construction of the carbazole nucleus as key-step. @ 1997 Elsevier Science Ltd. The carbazomycins A to H were isolated by Nakamura and co-worker