𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transition metal complexes in organic synthesis, part 38. First total synthesis of carbazomycin G and H

✍ Scribed by Hans-Joachim Knölker; Wolfgang Fröhner

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
293 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The first total synthesis of the carbazole quinol alkaloids carbazomycin G and H has been achieved by a highly convergent synthesis using an iron-mediated construction of the carbazole nucleus as key-step. @ 1997 Elsevier Science Ltd.

The carbazomycins A to H were isolated by Nakamura and co-workers from Streptoverticillium ehimense.2

📜 SIMILAR VOLUMES

Transition Metal-Diene Complexes in Orga
Transition Metal-Diene Complexes in Organic Synthesis. Part 15. Iron-mediated total synthesis of carbazomycin A and B
✍ Hans-Joachim Knölker; Michael Bauermeister 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 945 KB

Evidence for the structure of 13 was provided by the sharp s at 12.67 ppm (phenol OH) in the 'H-NMR spectrum. The substitution pattern was confirmed by NOE difference spectra. Irradiation at the Me signal at 2.28 ppm resulted in a NOE of the aromatic proton at 6.67 ppm.