Transition metal complexes in organic synthesis-44. Iron-mediated synthesis of indolo[2,3-b]carbazole
✍ Scribed by Hans-Joachim Knölker; Kethiri R. Reddy
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 129 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A straightforward two-step synthesis of indolo[2,3-b]carbazole using a double iron-mediated arylamine eyelization as the key-step is described.
📜 SIMILAR VOLUMES
AbstractÐA highly convergent synthesis provides indolo [2,3-b]carbazole in two steps and 36% overall yield from commercial m-phenylenediamine by a double iron-mediated consecutive C±C and C±N bond formation featuring the ®rst double iron-mediated arylamine cyclization.
Evidence for the structure of 13 was provided by the sharp s at 12.67 ppm (phenol OH) in the 'H-NMR spectrum. The substitution pattern was confirmed by NOE difference spectra. Irradiation at the Me signal at 2.28 ppm resulted in a NOE of the aromatic proton at 6.67 ppm.
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