Transition-Metal-Catalyzed Alkylations of Amines with Alkyl Halides: Photoinduced, Copper-Catalyzed Couplings of Carbazoles
โ Scribed by Bissember, Alex C.; Lundgren, Rylan J.; Creutz, Sidney E.; Peters, Jonas C.; Fu, Gregory C.
- Book ID
- 120158245
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 539 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
SmI\_JHMPA converts alkyl iodides and bromides to alkyl samarium reagents which can be crosscoupled with primary alkyl icdides and bromides and secondary iodides in the presence of Cu(I) halides or L&CuCl, at room temperature. The alkylation of primary iodides gives good yields of cross-coupling pro
G amines with various heteroaryl halides have been achieved by ligand-free copper-catalyzed cross-couplings affording aminopyridines and aminopyrimidines in moderate to high yields (up to 99% yield).