Ligand-Free Copper-Catalyzed Amination of Heteroaryl Halides with Alkyl- and Arylamines

✍ Scribed by Zhen-Jiang Liu; Jean-Pierre Vors; Ernst R. F. Gesing; Carsten Bolm

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 183 KB
• Volume: 352
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000708

✦ Synopsis

G amines with various heteroaryl halides have been achieved by ligand-free copper-catalyzed cross-couplings affording aminopyridines and aminopyrimidines in moderate to high yields (up to 99% yield).