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Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells

✍ Scribed by Lung-Ta Lee; Ying-Tang Huang; Jiuan-Jiuan Hwang; Amy Y.-L Lee; Ferng-Chun Ke; Chang-Jen Huang; Chithan Kandaswami; Ping-Ping H Lee; Ming-Ting Lee

Book ID
113487130
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
567 KB
Volume
67
Category
Article
ISSN
0006-2952

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## Abstract Tyrosine phosphorylation of the nonreceptor tyrosine kinase p125 focal adhesion kinase (FAK) and the adapter protein paxillin is rapidly increased by multiple agonists, including bombesin (BOM) and lysophosphatidic acid (LPA), through heptahelical G protein‐coupled receptors (GPCRs). Th