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The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses Proliferation and Invasion of Human Oral Squamous Carcinoma Cells via p53 Independent and MMP, uPAR Dependent Mechanism

✍ Scribed by EUN JU LEE; JIN HA WHANG; NAM KYEONG JEON; JIN KIM

Book ID
111483339
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
189 KB
Volume
1095
Category
Article
ISSN
0890-6564

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## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 (‘Iressa’) is an orally active, selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways