## Abstract In adult rats, using the singleβpass brain uptake technique with a tritiated water standard, Lβphenylalanine was shown to enter brain across the bloodβbrain barrier (BBB) by both a saturable and diffusionary process. A kinetic analysis of the data revealed Michaelis constant (K~a~) of 0
Transient transport across the blood-retina barrier
β Scribed by Jesper Larsen; Henrik Lund-Andersen; Bent Krogsaa
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 389 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1522-9602
No coin nor oath required. For personal study only.
β¦ Synopsis
A mathematical model of the transport of fluorescein across the blood-retina barrier in the transient state and the subsequent diffusion of fluorescein in the vitreous body is presented. The function of the barrier is lumped in a single parameter--the permeability. The sensitivity of this parameter due to changes in the other parameters of the model is given. This establishes the foundation for the quantitative assessment of the barrier function through vitreous fluorophotometry.
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