A large cardiac rhabdomyoma protruding into the left ventricle was diagnosed in a fetus at 21+2 weeks of gestation by grey-scale echocardiography. Obstruction to left ventricular outflow was ruled out by colour and spectral Doppler echocardiography. No other abnormalities were noted and karyotyping
Transient leukemia with trisomy 21: Description of a case and review of the literature
β Scribed by Bhatt, Sucheta ;Schreck, Rhona ;Graham, John M. ;Korenberg, Julie R. ;Hurvitz, Carole G. ;Fischel-Ghodsian, Nathan
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 590 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Transient myeloproliferative disorder (TMD) is an uncommon syndrome strongly associated with abnormalities of chromosome 21. Blast transient proliferation appears most frequently at neonatal age and usually resolves spontaneously in two or three months. Two patients, a girl and a boy,
I have read with great interest the paper by Crowe et al. [1997]. It is an excellent clinical and cytogenetic review of trisomy 22 in its various manifestations. I only wish to point out that the first proven case (by G-banding) of trisomy 22 appeared in 1973, in a paper in which we demonstrated the
In a case of mosaic trisomy 22 the trisomic cells were detected primarily in fibroblasts. Results of initial lymphocyte chromosome analysis were normal. However, mosaicism was suspected because the patient had hypomelanosis of Ito, hemiatrophy, failure to thrive, and mental retardation. Mosaicism wa