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Mosaic trisomy 22: A case presentation and literature review of trisomy 22 phenotypes

✍ Scribed by Hirschhorn, Kurt

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 855 B
Volume: 76
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19980413)76:5<447::aid-ajmg15>3.0.co;2-m

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✦ Synopsis

I have read with great interest the paper by Crowe et al. [1997]. It is an excellent clinical and cytogenetic review of trisomy 22 in its various manifestations. I only wish to point out that the first proven case (by G-banding) of trisomy 22 appeared in 1973, in a paper in which we demonstrated the power of banding inprecise identification of chromosomal abnormalities [Hirschhorn et al., 1973]. This paper seems to be somewhat lost in the cytogenetic literature [see Hirschhorn, 1996].

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