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Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex †

✍ Scribed by Sydor, Jens R.; Engelhard, Martin; Wittinghofer, Alfred; Goody, Roger S.; Herrmann, Christian


Book ID
120011852
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
148 KB
Volume
37
Category
Article
ISSN
0006-2960

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ