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Transient defects of mitotic spindle geometry and chromosome segregation errors

✍ Scribed by Silkworth, William T; Cimini, Daniela


Book ID
119910528
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
350 KB
Volume
7
Category
Article
ISSN
1747-1028

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## Abstract Mitotic catastrophe is a form of cell death that results from aberrant mitosis. Currently, the mechanisms involved in this form of cell death remain poorly understood. We found that actinomycin D induces mitotic catastrophe with severe spindle assembly defects. We have studied the natur