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Transgenic mouse models of dopamine deficiency

โœ Scribed by Linan Chen; Xiaoxi Zhuang


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
108 KB
Volume
54
Category
Article
ISSN
0364-5134

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## Abstract Parkinson's disease (PD) is characterized by loss of nigral dopaminergic (DAergic) neurons and presence of Lewy bodies, whose major component is ฮฑโ€synuclein. We had previously generated transgenic mice termed __Syn130m__ that express truncated human ฮฑโ€synuclein (amino acid residues 1โ€“13