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Transgenic mouse model for human genetic diseases

✍ Scribed by Ken-Ichi Yamamura; Fumi Tashiro; Shigehiro Yi; Shoji Wakasugi; Shukuro Araki; Shuichiro Maeda; Kazunori Shimada


Book ID
111662533
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
270 KB
Volume
36
Category
Article
ISSN
1040-452X

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To study the molecular mechanism for the development of B-cell dominant autoimmune diseases, several autoantibody transgenic mouse models were established. These studies have revealed that the escape of autoreactive B cells from clonal deletion or functional inactivation (clonal anergy) alone is not